Decentralized molecular analytics for fast result generation

PCR Player and isothermal reader

ESEQuant TS2 tube scanner for isothermal amplification.

Because sometimes the lab has to come to you

The ESEQuant TS2 is an easy-to-use fluorescence measurement system for isothermal nucleic acid amplification and fluorescence analysis in other applications. The instrument is extremely sensitive, robust and ideal for small labs or even off-site testing. Utilizing a fluorescence detector based on modern microsystems technology and state-of-the-art light-emitting diode (LED) and filter technology, the sensitivity of the tube scanner is comparable to top-of-the range commercial spectrophotometers.

Small instrument for standalone use
Customizable system with short time to market
Developed for regulated markets (IVD/FDA ready)
Highly-reliable measurements with optical self-check
Multiple connectivity options

Intuitive instrument user interface with high usability
Online growth curve view
3-click run start
Multi-language support
Bar code sample and test entry
Supports the regulation requirements of Clinical
Laboratory Improvement Amendments (CLIA)

Batch processing of your data sets
Quickly apply different algorithm settings to a batch of raw data
Define algorithm settings on solid statistical base
Visualize your growth curves with many filter, sorting and color options
Export your analysis to Microsoft Excel spreadsheet or print the results

Powerful software suite with easy 3-step test design
Set your measurement parameter (e.g. temperature profile, wavelength or interrupt workflow)
Select and assign algorithms for your individual measurement channels
Create one result by easily combining data from individual channels
Generate reports

Housing
Approx. weight 4 kg (8.8 lb)
Small footprint of 23 x 20 x 14 cm (9.1 x 7.9 x 5.5 in)
Optics
Up to 6 discrete wavelength combinations detected per tube, covering 3 orders of magnitude signal intensity
Covers the spectrum between 365 and 720 nm
Internal self-check using fluorescence reference material
Broad sensitivity range
Temperature unit
Incubation of 12 standard PCR tubes
Peltier-based heating/cooling system capable of attaining 15–95°C (59–203°F)
Redundant sensors for surveillance functionality
Electronics
Interactive 17.8 cm (7 in) touchscreen
Internal 1D/2D-bar code reader
Ethernet and 4 USB A/B ports
Mains operation
Interfaces
LIS (Laboratory Information System) support using HL7 protocol
External bar code reader
Label or office printer connectability
Miscellaneous
Multiple assay evaluation settings and data processing software
Documentation for submission into regulated markets available

ESEQuant TS2.4*

For measurement of 4 wavelengths simultaneously

detects Alexa Fluor 350, Coumarin, DyLight 350, Marina Blue®, or similar detects ROX, Texas Red, Alexa Fluor 568, DyLight 594, Killer Red, HEX, or similar detects FAMTM, SYBR Green I, Alexa Fluor 488, DyLight 488, FITC, or similar detects Cy5, Alexa Fluor 633, Nile Blue, or similar

Cat. no.: Inquire

ESEQuant TS2.x*

Customized for other wavelengths

Cat. no.: Inquire

* All starter kits include the ESEQuant TS2 with the selected wavelengths, tube holder for 12 x 200 μl standard PCR tubes, internal bar code reader, PC software, and power cord with worldwide plug.

Not for use in diagnostic procedures. For up-to-date licensing information and product-specific disclaimers, see the respective hand book or user manual. DIALUNOX kit hand books and user manuals are available at www.dialunox.com or can be requested from our technical services.

What else could we offer?

At DIALUNOX, innovation is at the core of everything we do. Our engineering team is dedicated to creating state-of-the-art molecular testing solutions tailored to your needs. We invite you to explore our potential product proposals, each ready for rapid development and production. Connect with us to discuss how we can partner to achieve your goals and drive progress together.

Property	Isothermal handheld	Isothermal lab reader	Isothermal fully integrated	rtPCR fully integrated

Sample preparation (NA extraction + MMx setup)	manually	manually	internally fully automated	internally fully automated
NA amplification	small peltier or heat foil for isothermal amplification	air fan for isothermal amplification	air fan for isothermal or slow PCR	Peltier-based for fast PCR
Detection	3 wavelength fluorescence detector	6 wavelength fluorescence detector	4 wavelength fluorescence detector	4 wavelength fluorescence detector
Operation and result review	smartphone app	touch display	touch buttons / LIS interface / app interface / touch display	touch buttons / LIS interface / app interface / touch display

Solutions for molecular testing

Product description	A handheld isothermal amplification device for one standard PCR tube equipped with a high sensitive fluoresence detector. The detector can detect 3 different wavelength combinations. Standard PCR tubes can be incubated between 30° and 70° ideal for all common isothermal reactions. The rechargeable battery allows operation without permanent power supply for hours.
Development stage / Modification options	Design mockup based on pre-developed modules from DLX specifically the detection unit. Customer can choose several modifications like sample insert to be fitted for special disposables, touch display and other options
Throughput	One sample/tube per run
Multiplexing capacity (ability to detect different parameters within one run from one sample)	Up to 3 analytes per run using 3 different dyes per reaction
Development timeline	3 month until functional module; 12 month until series start

Product Description	Small Footprint lab instrument for 6 samples per run. The rotor ensures homogenious temperature incubation of samples and spins down eluates to avoid bubbles and residuals. Measurement from below using DLX high sensitive fluorescence detectors. The multi functional touch display guides the user through ordering process and displays results and growth curves.
Development Stage / Modification Options	Design mockup based on pre-developed modules from DLX specifically the detection and heating unit. Calibration and measurement principles from previous versions (TS1, TS2) will allow a straight forward low risk development. Customer requests like amount of samples, different tube types or other applications like NA quantification can be considered during development
Throughput	6 samples per run
Multiplexing capacity (ability to detect different parameter within one run from one sample)	Up to 6 analytes per run using 6 different dyes per reaction
Development Timeline	4 month until functional module; 18 month until series start

Product Description	Sample to answer instrument using centrifugal microfluidic cartridges. Complete lab workflows from NA extraction, isothermal amplification, libary prep, digital PCR can be realized on this platform using pre-stored dried reagents on the disk. The system incubates samples works using air fan heating and cooling for applications which require lower heating ramps
Development Stage / Modification Options	Prototype available. Customer can start with partner of DLX to develop it`s own unique workflow on the lab disk. DLX will adapt plate holder according customized lab disk. Final instrument gets developed among customer needs.
Throughput	1-2 samples per run
Multiplexing capacity (ability to detect different parameter within one run from one sample)	Up to 30-plex multiplexing through aliquoting samples into different reaction chambers.
Development Timeline	6 month until functional module; 18 month until series start. Strongly dependend on lab disk development and production

Product Description	Sample to answer instrument using centrifugal microfluidic cartridges. Complete lab workflows from NA extraction, fast rtPCR, libary prep, digital PCR can be realized on this platform using pre-stored dried reagents on the disk.
Development Stage / Modification Options	Developed instrument already in production. Customer can start with partner of DLX to develop it`s own unique workflow on the lab disk. DLX will adapt plate holder according customized lab disk.
Throughput	1-2 samples per run
Multiplexing capacity (ability to detect different parameter within one run from one sample)	Up to 30-plex multiplexing through aliquoting samples into different reaction chambers.
Development Timeline	6 month until functional module; 12 month until series start. Strongly dependend on lab disk development and production